Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | substrate 2,6-dichlorophenolindophenol, about 10fold increase in activity in presence of calmodulin | Drosophila melanogaster |
General Stability | Organism |
---|---|
very stable against trypsin, reductase domain is much more susceptible to urea than oxygenase domain | Drosophila melanogaster |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
152000 | - |
x * 152000, SDS-PAGE, plus a proteolytic artefact of 121000 | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
expression in Escherichia coli | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
flavoprotein | - |
Drosophila melanogaster |
additional information | hemoprotein | Drosophila melanogaster |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,6-dichlorophenolindophenol + NADPH + O2 | best substrate, about 10-fold increase in activity in presence of calmodulin | Drosophila melanogaster | ? + NO + NADP+ | - |
? | |
ferricyanide + NADPH + O2 | - |
Drosophila melanogaster | ferrocyanide + NADP+ + ? | - |
? | |
ferricytochrome c + NADPH + O2 | - |
Drosophila melanogaster | ferrocytochrome c + NO + NADP+ | - |
? | |
L-arginine + H2O2 + tetrahydrobiopterin | - |
Drosophila melanogaster | ? + NO + NADP+ | - |
? | |
L-arginine + NADPH + O2 + tetrahydrobiopterin | - |
Drosophila melanogaster | citrulline + NO + NADP+ + ? | - |
? | |
N-hydroxy-L-arginine + H2O2 + tetrahydrobiopterin | - |
Drosophila melanogaster | ? + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 152000, SDS-PAGE, plus a proteolytic artefact of 121000 | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
DNOS | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | - |
Drosophila melanogaster | |
NADPH | - |
Drosophila melanogaster |