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Literature summary for 1.14.13.34 extracted from

  • Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
    Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro (1992), Eur. J. Biochem., 206, 869-897.
    View publication on PubMed
Search for more literature for 1.14.13.34

Inhibitors

Inhibitors Comment Organism Structure
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate competitively inhibits leukotriene E4 omega-oxidation Rattus norvegicus
Halothane induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 phenobarbital-treated
-
Rattus norvegicus
-
 male Sprague Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 leukotriene E4 Rattus norvegicus 20-hydroxy-leukotriene E4 + NADP+ + H2O omega-hydroxy-leukotriene E4 ?
N-acetyl-leukotriene E4 + NADPH + O2
-
 Rattus norvegicus N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus
O2
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.08
-
 (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
-
 Rattus norvegicus