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Literature summary for 1.14.13.242 extracted from

  • Sparrow, L.G.; Ho, P.P.K.; Sundaram, T.K.; Zach, D.; Nyns, E.J.; Snell, E.E.
    The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring (1969), J. Biol. Chem., 244, 2590-2600.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Pseudomonas sp.

Inhibitors

Inhibitors Comment Organism Structure
5-pyridoxic acid competitive with 3-hydroxy-2-methylpyridine-5-carboxylate Pseudomonas sp.
6-Methylnicotinate
-
Pseudomonas sp.
6-methylnicotinic acid competitive with 3-hydroxy-2-methylpyridine-5-carboxylate Pseudomonas sp.
p-chloromercuribenzoate 0.05 mM, quick and complete inhibition Pseudomonas sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
166000
-
equilibrium sedimentation Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 Pseudomonas sp. inducible enzyme opens the pyridine ring during the metabolic degradation of vitamin B6 2-(acetamidomethylene)succinate + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
MA-1
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas sp.

Reaction

Reaction Comment Organism Reaction ID
3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2 = 2-(acetamidomethylidene)succinate + NAD(P)+ reaction proceeds in a concerted fashion via a ternary complex of oxygenase, NADH and 3-hydroxy-2-methylpyridine-5-carboxylate Pseudomonas sp.

Storage Stability

Storage Stability Organism
-20°C, 50% glycerol, 0.1% 2-mercaptoethanol, 1 month Pseudomonas sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2
-
Pseudomonas sp. 2-(acetamidomethylene)succinate + NAD(P)+
-
?
3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 inducible enzyme opens the pyridine ring during the metabolic degradation of vitamin B6 Pseudomonas sp. 2-(acetamidomethylene)succinate + NAD+
-
?
5-pyridoxic acid + NADH + O2
-
Pseudomonas sp. ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 8
-
Pseudomonas sp.

Cofactor

Cofactor Comment Organism Structure
FAD contains 2 mol of FAD per mol of enzyme Pseudomonas sp.
NADH
-
Pseudomonas sp.