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Literature summary for 1.14.13.239 extracted from

  • Koeth, R.; Levison, B.; Culley, M.; Buffa, J.; Wang, Z.; Gregory, J.; Org, E.; Wu, Y.; Li, L.; Smith, J.; Tang, W.; Didonato, J.; Lusis, A.; Hazen, S.
    gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO (2014), Cell Metab., 20, 799-812 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21pLysS cells Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-carnitine + NADH + H+ + O2 Escherichia coli
-
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
?
L-carnitine + NADH + H+ + O2 Escherichia coli DH10B
-
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
?
L-carnitine + NADPH + H+ + O2 Escherichia coli
-
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
?
L-carnitine + NADPH + H+ + O2 Escherichia coli DH10B
-
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli DH10B
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-carnitine + NADH + H+ + O2
-
Escherichia coli (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
?
L-carnitine + NADH + H+ + O2
-
Escherichia coli DH10B (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
?
L-carnitine + NADPH + H+ + O2
-
Escherichia coli (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
?
L-carnitine + NADPH + H+ + O2
-
Escherichia coli DH10B (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
carnitine TMA lyase
-
Escherichia coli
yeaWX
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADH
-
Escherichia coli
NADPH
-
Escherichia coli