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Literature summary for 1.14.13.236 extracted from

  • Moe, L.A.; Hu, Z.; Deng, D.; Austin, R.N.; Groves, J.T.; Fox, B.G.
    Remarkable aliphatic hydroxylation by the diiron enzyme toluene 4-monooxygenase in reactions with radical or cation diagnostic probes norcarane, 1,1-dimethylcyclopropane, and 1,1-diethylcyclopropane (2004), Biochemistry, 43, 15688-15701.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
T201A parameters similar to wild-type Pseudomonas mendocina
T201L parameters similar to wild-type Pseudomonas mendocina
T201S parameters similar to wild-type Pseudomonas mendocina

Organism

Organism UniProt Comment Textmining
Pseudomonas mendocina Q00456 and Q00457 and Q00460 Q00456, Q00457 and Q00460 are components TmoA, TmoB and TmoE of diiron hydroxylase T4MOH, respectively
-
Pseudomonas mendocina KR1 Q00456 and Q00457 and Q00460 Q00456, Q00457 and Q00460 are components TmoA, TmoB and TmoE of diiron hydroxylase T4MOH, respectively
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,1-diethylcyclopropane + NADH + H+ + O2
-
Pseudomonas mendocina ? + NAD+ + H2O
-
?
1,1-diethylcyclopropane + NADH + H+ + O2
-
Pseudomonas mendocina KR1 ? + NAD+ + H2O
-
?
1,1-dimethylcyclopropane + NADH + H+ + O2
-
Pseudomonas mendocina ? + NAD+ + H2O
-
?
1,1-dimethylcyclopropane + NADH + H+ + O2
-
Pseudomonas mendocina KR1 ? + NAD+ + H2O
-
?
additional information products are consistent with both radical rearrangement and cation ring expansion. Products show high-fidelity incorporation of an O-atom from O2 in the un-rearranged and radical-rearranged products, while the O-atom found in the cation ring-expansion products is predominantly obtained by reaction with H2O Pseudomonas mendocina ?
-
?
additional information products are consistent with both radical rearrangement and cation ring expansion. Products show high-fidelity incorporation of an O-atom from O2 in the un-rearranged and radical-rearranged products, while the O-atom found in the cation ring-expansion products is predominantly obtained by reaction with H2O Pseudomonas mendocina KR1 ?
-
?
norcarane + NADH + H+ + O2
-
Pseudomonas mendocina endo-2-norcaranol + exo-2-norcaranol + endo-3-norcaranol + NAD+ + H2O 72% coupling, 47.5% endo-2-norcaranol, 39.2% exo-2- and endo-3-norcaranol, 8.8% exo-3-norcaranol ?
norcarane + NADH + H+ + O2
-
Pseudomonas mendocina KR1 endo-2-norcaranol + exo-2-norcaranol + endo-3-norcaranol + NAD+ + H2O 72% coupling, 47.5% endo-2-norcaranol, 39.2% exo-2- and endo-3-norcaranol, 8.8% exo-3-norcaranol ?
toluene + NADH + H+ + O2
-
Pseudomonas mendocina 4-methylphenol + NAD+ + H2O 94% coupling ?
toluene + NADH + H+ + O2
-
Pseudomonas mendocina KR1 4-methylphenol + NAD+ + H2O 94% coupling ?

Synonyms

Synonyms Comment Organism
T4MOH
-
Pseudomonas mendocina

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.35
-
norcarane mutant T201S, pH 7.5, 25°C Pseudomonas mendocina
0.4
-
norcarane mutant T201A, pH 7.5, 25°C Pseudomonas mendocina
0.46
-
norcarane mutant T201L, pH 7.5, 25°C Pseudomonas mendocina
0.49
-
norcarane wild-type, pH 7.5, 25°C Pseudomonas mendocina
1.9
-
Toluene mutant T201L, pH 7.5, 25°C Pseudomonas mendocina
1.9
-
Toluene mutant T201S, pH 7.5, 25°C Pseudomonas mendocina
2.3
-
Toluene wild-type, pH 7.5, 25°C Pseudomonas mendocina
2.3
-
Toluene mutant T201A, pH 7.5, 25°C Pseudomonas mendocina