Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cofilin | cofilin enhances Mical-mediated actin filament disassembly. Mical and cofilin synergize to drive Semaphorin-Plexin repulsive signalling and axon guidance | Drosophila melanogaster | |
F-actin | actin regulatory protein cofilin strongly suppresses the ability of F-actin to trigger Mical-mediated NADPH consumption | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q86BA1 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | F-actin is efficiently dismantled through a post-translational-mediated synergism between cofilin and the actin-oxidizing enzyme Mical. Mical-mediated oxidation of actin improves cofilin binding to filaments, where their combined effect dramatically accelerates F-actin disassembly compared with either effector alone. This synergism is also necessary and sufficient for F-actin disassembly in vivo, magnifying the effects of both Mical and cofilin on cellular remodelling, axon guidance and Semaphorin-Plexin repulsion | Drosophila melanogaster |