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Literature summary for 1.14.13.2 extracted from

  • Spector, T.; Massey, V.
    Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens (1972), J. Biol. Chem., 247, 4679-4687.
    View publication on PubMed
Search for more literature for 1.14.13.2

Activating Compound

Activating Compound Comment Organism Structure
2,4-Dihydroxybenzoate increases the rate of NADP oxidation by 4-hydroxybenzoate, no hydroxylation during subsequent reoxidation by O2 Pseudomonas fluorescens
3,4-dihydroxybenzoate increases the rate of NADP oxidation by 4-hydroxybenzoate, no hydroxylation during subsequent reoxidation by O2 Pseudomonas fluorescens
benzoate increases the rate of NADP oxidation by 4-hydroxybenzoate, no hydroxylation during subsequent reoxidation by O2 Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
3,4-dihydroxybenzoate at high concentration Pseudomonas fluorescens
4-Aminobenzoate
-
 Pseudomonas fluorescens
4-Fluorobenzoate slight Pseudomonas fluorescens
4-hydroxybenzaldehyde slight Pseudomonas fluorescens
4-hydroxybenzoate at high concentrations Pseudomonas fluorescens
4-hydroxycinnamate
-
 Pseudomonas fluorescens
6-Hydroxynicotinate at high concentrations Pseudomonas fluorescens
benzoate slight Pseudomonas fluorescens
salicylate slight Pseudomonas fluorescens

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dihydroxybenzoate + NADPH + O2
-
 Pseudomonas fluorescens 2,3,4-trihydroxybenzoate + 2,4,5-trihydroxybenzoate + NADP+ + H2O
-
 ?
4-hydroxybenzoate + NADPH + O2
-
 Pseudomonas fluorescens protocatechuate + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Pseudomonas fluorescens