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Literature summary for 1.14.13.163 extracted from

  • Wang, S.; Huang, H.; Xie, K.; Xu, P.
    Identification of nicotine biotransformation intermediates by Agrobacterium tumefaciens strain S33 suggests a novel nicotine degradation pathway (2012), Appl. Microbiol. Biotechnol., 95, 1567-1578.
    View publication on PubMed
Search for more literature for 1.14.13.163

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens
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-
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Agrobacterium tumefaciens S33
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-hydroxy-3-succinoylpyridine + 2 NADH + 2 H+ + O2
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 Agrobacterium tumefaciens 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
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 ?
6-hydroxy-3-succinoylpyridine + 2 NADH + 2 H+ + O2
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 Agrobacterium tumefaciens S33 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
HSPH
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 Agrobacterium tumefaciens

General Information

General Information Comment Organism
physiological function strain S33 can transform nicotine into renewable hydroxylated-pyridine intermediates by a special pathway, in which at least three intermediates, 6-hydroxy-L-nicotine, 6-hydroxy-3-succinoylpyridine, and 2,5-dihydroxypyridine, have potential to be further chemically modified into useful compounds. Strain S33 is able to transform nicotine to 6-hydroxy-pseudooxynicotine first via the pyridine pathway through 6-hydroxy-L-nicotine and 6-hydroxy-N-methylmyosmine, and then, it turns to the pyrrolidine pathway with the formation of 6-hydroxy-3-succinoylpyridine and 2,5-dihydroxypyridine Agrobacterium tumefaciens