Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.148 extracted from

  • Fedejko-Kap, B.; Niemira, M.; Radominska-Pandya, A.; Mazerska, Z.
    Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells (2011), Xenobiotica, 41, 1044-1055.
    View publication on PubMed
Search for more literature for 1.14.13.148

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1116
-
 5-{[3-(dimethylamino)propyl]amino}-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one isozyme FMO3, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C Homo sapiens
0.1624
-
 5-{[3-(dimethylamino)propyl]amino}-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one isozyme FMO3, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513 isozyme FMO3
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-{[3-(dimethylamino)propyl]amino}-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone Rattus norvegicus 5-{[3-(dimethylnitroryl)propyl]amino}-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-{[3-(dimethylamino)propyl]amino}-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone Homo sapiens 5-{[3-(dimethylnitroryl)propyl]amino}-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-{[3-(dimethylamino)propyl]amino}-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2
-
 Rattus norvegicus 5-{[3-(dimethylnitroryl)propyl]amino}-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-{[3-(dimethylamino)propyl]amino}-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2
-
 Homo sapiens 5-{[3-(dimethylnitroryl)propyl]amino}-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase
-
 Rattus norvegicus
flavin-containing monooxygenase
-
 Homo sapiens
FMO3 isozyme Rattus norvegicus
FMO3 isozyme Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.4 8.4 the activity is approximately twice as high at pH 8.4 as at pH 7.4 Rattus norvegicus
7.4 8.4 the activity is approximately twice as high at pH 8.4 as at pH 7.4 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus
FAD
-
 Homo sapiens
NADPH required for activity Rattus norvegicus
NADPH required for activity Homo sapiens

General Information

General Information Comment Organism
metabolism the flavin monooxygenase FMO3 contributes to metabolism of anti-tumour triazoloacridinone, C-1305 (5-dimethylaminopropylamino-8-hydroxytriazoloacridinone), in liver microsomes Rattus norvegicus
metabolism the flavin monooxygenase FMO3 contributes to metabolism of anti-tumour triazoloacridinone, C-1305 (5-dimethylaminopropylamino-8-hydroxytriazoloacridinone), in liver microsomes and Hep-G2 cells Homo sapiens