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Literature summary for 1.14.13.148 extracted from

  • Burnettt, V.; Lawton, M.; Philpot, R.
    Cloning and sequencing of flavin-containing monooxygenases FMO3 and FMO4 from rabbit and characterization of FMO3 (1994), J. Biol. Chem., 269, 14314-14322.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information n-octylamine has no effect on isoform FMO3 Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain 334 and in Escherichia coli JM109 cells Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine
-
Oryctolagus cuniculus
prochlorperazine
-
Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
Methimazole isoform FMO3, at pH 8.4, temperature not specified in the publication Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59815
-
59815, isofom FMO3, calculated from amino acid sequence Oryctolagus cuniculus
62992
-
x * 62992, isoform FMO4, calculated from amino acid sequence Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P32417 isoform FMO3
-
Oryctolagus cuniculus P36367 isoform FMO4
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney isoform FMO4 is most prominent in the kidney Oryctolagus cuniculus
-
liver isoform FMO3 is most prominent in the liver Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.025
-
isoform FMO3, using 1 mM methimazole as substrate, at pH 8.4, temperature not specified in the publication Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methimazole + NADPH + H+ + O2
-
Oryctolagus cuniculus methimazole N-oxide + NADP+ + H2O
-
?

Subunits

Subunits Comment Organism
? 59815, isofom FMO3, calculated from amino acid sequence Oryctolagus cuniculus
? x * 62992, isoform FMO4, calculated from amino acid sequence Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
EC 1.14.13.8 assigned to Oryctolagus cuniculus
flavin-containing monooxygenase
-
Oryctolagus cuniculus
FMO3 isoform Oryctolagus cuniculus
FMO4 isoform Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Oryctolagus cuniculus
NADPH required for activity Oryctolagus cuniculus