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Literature summary for 1.14.13.148 extracted from

  • Dolphin, C.; Riley, J.; Smith L, R.; Shephard, E.; Phillips, I.
    Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA (1997), Genomics, 46, 260-267.
    View publication on PubMed
Search for more literature for 1.14.13.148

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N,N-trimethylamine + NADPH + H+ + O2 Homo sapiens
-
 N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver FMO3 is the major form of flavin-containing monooxygenase expressed in adult human liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N,N-trimethylamine + NADPH + H+ + O2
-
 Homo sapiens N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
EC 1.14.13.8 assigned to Homo sapiens
flavin-containing monooxygenase 3
-
 Homo sapiens
FMO3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH dependent on Homo sapiens

General Information

General Information Comment Organism
malfunction trimethylaminuria (fish-odor syndrome) is associated with defective hepatic N-oxidation of dietary-derived trimethylamine catalyzed by flavin-containing monooxygenase Homo sapiens