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Literature summary for 1.14.13.101 extracted from

  • Naumann, C.; Hartmann, T.; Ober, D.
    Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-defended arctiid moth Tyria jacobaeae (2002), Proc. natl. Acad. Sci. USA, 99, 6085-6090.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in active form in Escherichia coli BL21 Tyria jacobaeae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Tyria jacobaeae the enzyme allows the larvae to feed on pyrrolizidine alkaloid-containing plants and to accumulate predation-deterrent pyrrolizidine alkaloids in the hemolymph ?
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?

Organism

Organism UniProt Comment Textmining
Tyria jacobaeae Q8MP06 sinnabar moth
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Source Tissue

Source Tissue Comment Organism Textmining
hemolymph
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Tyria jacobaeae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
axillarine + NADPH + O2 74% of the activity with senecionine, native enzyme. 83% of the activity with senecionine, recombinant enzyme Tyria jacobaeae axillarine N-oxide + NADP+ + H2O
-
?
heliotrine + NADPH + O2 25% of the activity with senecionine, native enzyme. 49% of the activity with senecionine, recombinant enzyme Tyria jacobaeae heliotrine N-oxide + NADP+ + H2O
-
?
monocrotaline + NADPH + O2 92% of the activity with senecionine, native enzyme. 94% of the activity with senecionine, recombinant enzyme Tyria jacobaeae monocrotaline N-oxide + NADP+ + H2O
-
?
additional information the enzyme is highly specific for toxic pyrrolizidine alkaloids. No activity with: senkirkine, dimethylaniline, L-Pro, caffeine, atropine, supinidine, retronecine, phalaenopsine Tyria jacobaeae ?
-
?
additional information the enzyme allows the larvae to feed on pyrrolizidine alkaloid-containing plants and to accumulate predation-deterrent pyrrolizidine alkaloids in the hemolymph Tyria jacobaeae ?
-
?
senecionine + NADPH + O2
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Tyria jacobaeae senecionine N-oxide + NADP+ + H2O
-
?
seneciphylline + NADPH + O2 95% of the activity with senecionine, native enzyme. 93% of the activity with senecionine, recombinant enzyme Tyria jacobaeae seneciphylline N-oxide + NADP+ + H2O
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?

Synonyms

Synonyms Comment Organism
oxygenase, senecionine N-
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Tyria jacobaeae
senecionine N-oxygenase
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Tyria jacobaeae
SNO
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Tyria jacobaeae

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Tyria jacobaeae