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Literature summary for 1.14.13.1 extracted from

  • Santos, H.; Lang, E.; Segato, F.; Rossi, A.; Martinez-Rossi, N.
    Terbinafine resistance conferred by multiple copies of the salicylate 1-monooxygenase gene in Trichophyton rubrum (2018), Med. Mycol., 56, 378-381 .
    View publication on PubMed
Search for more literature for 1.14.13.1

Cloned(Commentary)

Cloned (Comment) Organism
gene salA, quantitative RT-PCR enzyme expression analysis Trichophyton rubrum

Protein Variants

Protein Variants Comment Organism
additional information construction of a strain with multiple copies of salA via protoplast transformations, the mutant exhibits elevated expression of salA and increased terbinafine resistance Trichophyton rubrum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
salicylate + NADH + 2 H+ + O2 Trichophyton rubrum
-
 catechol + NAD+ + H2O + CO2
-
 ?
salicylate + NADH + 2 H+ + O2 Trichophyton rubrum CBS118892
-
 catechol + NAD+ + H2O + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Trichophyton rubrum F2SJL1
-
-
Trichophyton rubrum CBS118892 F2SJL1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
salicylate + NADH + 2 H+ + O2
-
 Trichophyton rubrum catechol + NAD+ + H2O + CO2
-
 ?
salicylate + NADH + 2 H+ + O2
-
 Trichophyton rubrum CBS118892 catechol + NAD+ + H2O + CO2
-
 ?

Synonyms

Synonyms Comment Organism
salA
-
 Trichophyton rubrum
Salicylate 1-monooxygenase
-
 Trichophyton rubrum

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Trichophyton rubrum
NADH
-
 Trichophyton rubrum

Expression

Organism Comment Expression
Trichophyton rubrum gene salA is transcriptionally upregulated in Trichophyton rubrum in response to terbinafine up

General Information

General Information Comment Organism
malfunction a mutant strain with multiple copies of salA exhibits elevated expression of salA and increased terbinafine resistance Trichophyton rubrum
physiological function the salA gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte Trichophyton rubrum to terbinafine (TRB), one of the most effective antifungal drugs against dermatophytes. Resistance to TRB is mediated by multiple salA copies in Trichophyton rubrum. Salicylate 1-monooxygenase is an enzyme that participates in the naphthalene degradation pathway, converting the intermediate metabolite salicylic acid into catechol Trichophyton rubrum