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Literature summary for 1.14.12.17 extracted from
- Flavin-containing heme enzymes (2010), Arch. Biochem. Biophys., 493, 37-52.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Cupriavidus necator |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Cupriavidus necator |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carbon monoxide | competitive inhibition | Cupriavidus necator |  |
| carbon monoxide | competitive inhibition | Escherichia coli | |
| carbon monoxide | competitive inhibition | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
O2 | apparent KM | Saccharomyces cerevisiae | |
| 0.08 | - |
O2 | apparent KM | Cupriavidus necator | |
| 0.09 | - |
O2 | apparent KM | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nitric oxide + O2 + NAD(P)H | Saccharomyces cerevisiae | - |
nitrate + NAD(P)+ + H+ | - |
? | |
| nitric oxide + O2 + NAD(P)H | Escherichia coli | - |
nitrate + NAD(P)+ + H+ | - |
? | |
| nitric oxide + O2 + NAD(P)H | Cupriavidus necator | - |
nitrate + NAD(P)+ + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cupriavidus necator | P39662 | - |
- |
| Escherichia coli | P24232 | - |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Cupriavidus necator |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nitric oxide + O2 + NAD(P)H | - |
Saccharomyces cerevisiae | nitrate + NAD(P)+ + H+ | - |
? | |
| nitric oxide + O2 + NAD(P)H | - |
Escherichia coli | nitrate + NAD(P)+ + H+ | - |
? | |
| nitric oxide + O2 + NAD(P)H | - |
Cupriavidus necator | nitrate + NAD(P)+ + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| flavohemoglobin | - |
Saccharomyces cerevisiae |
| flavohemoglobin | - |
Escherichia coli |
| flavohemoglobin | - |
Cupriavidus necator |
| nitric oxide dioxygenase | - |
Saccharomyces cerevisiae |
| nitric oxide dioxygenase | - |
Escherichia coli |
| nitric oxide dioxygenase | - |
Cupriavidus necator |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | - |
Saccharomyces cerevisiae | |
| flavin | - |
Escherichia coli | |
| flavin | - |
Cupriavidus necator | |
| heme | - |
Saccharomyces cerevisiae | |
| heme | - |
Escherichia coli | |
| heme | - |
Cupriavidus necator | |
| NADH | - |
Saccharomyces cerevisiae | |
| NADH | - |
Escherichia coli | |
| NADH | - |
Cupriavidus necator | |
| NADPH | - |
Saccharomyces cerevisiae | |
| NADPH | - |
Escherichia coli | |
| NADPH | - |
Cupriavidus necator | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
carbon monoxide | Ki value less than 1 microM | Saccharomyces cerevisiae | |
| additional information | - |
carbon monoxide | Ki value less than 1 microM | Escherichia coli | |
| additional information | - |
carbon monoxide | Ki value less than 1 microM | Cupriavidus necator | |
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Release 2023.1 (January 2023)
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