Literature summary for 1.14.12.17 extracted from

Helmick, R.A.; Fletcher, A.E.; Gardner, A.M.; Gessner, C.R.; Hvitved, A.N.; Gustin, M.C.; Gardner, P.R.
Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin (2005), Antimicrob. Agents Chemother., 49, 1837-1843.

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Inhibitors

Inhibitors	Comment	Organism	Structure
clotrimazole	-	Candida albicans
clotrimazole	-	Escherichia coli
clotrimazole	-	Saccharomyces cerevisiae
econazole	-	Candida albicans
econazole	-	Escherichia coli
econazole	-	Saccharomyces cerevisiae
imidazole	imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism	Candida albicans
imidazole	imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism	Escherichia coli
imidazole	imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism	Saccharomyces cerevisiae
ketoconazole	-	Candida albicans
ketoconazole	-	Escherichia coli
ketoconazole	-	Saccharomyces cerevisiae
miconazole	competitive with respect to O2 and NO	Candida albicans
miconazole	competitive with respect to O2 and NO	Escherichia coli
miconazole	competitive with respect to O2 and NO	Saccharomyces cerevisiae
NO	high concentrations, competition with O2, augmented by miconazole	Candida albicans
NO	high concentrations, competition with O2, augmented by miconazole	Escherichia coli
NO	high concentrations, competition with O2, augmented by miconazole	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Escherichia coli	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NO + O2 + NADH	-	Escherichia coli	NO3- + NAD+	-	?
NO + O2 + NADH	-	Saccharomyces cerevisiae	NO3- + NAD+	-	?
NO + O2 + NADH	-	Candida albicans	NO3- + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
flavohemoglobin	-	Escherichia coli
flavohemoglobin	-	Saccharomyces cerevisiae
flavohemoglobin	-	Candida albicans
NOD	-	Escherichia coli
NOD	-	Saccharomyces cerevisiae
NOD	-	Candida albicans

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Escherichia coli
NADH	-	Saccharomyces cerevisiae
NADH	-	Candida albicans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00008	-	miconazole	-	Escherichia coli
0.000225	-	econazole	-	Candida albicans
0.00055	-	econazole	-	Escherichia coli
0.00065	-	clotrimazole	-	Candida albicans
0.0007	-	miconazole	-	Candida albicans
0.0013	-	clotrimazole	-	Escherichia coli
0.005	-	ketoconazole	-	Escherichia coli
0.012	-	miconazole	-	Saccharomyces cerevisiae
0.0125	-	ketoconazole	-	Candida albicans
0.03	-	econazole	-	Saccharomyces cerevisiae
0.05	-	clotrimazole	-	Saccharomyces cerevisiae
0.1	-	ketoconazole	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)