Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | KDM4A predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair | Drosophila melanogaster | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9V333 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-N6-methyl-L-lysine56 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyl-L-lysine56 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6,N6-dimethyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine56 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | [histone H3]-N6-methyl-L-lysine56 + succinate + formaldehyde + CO2 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage | Drosophila melanogaster |