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Literature summary for 1.14.11.8 extracted from

  • Vijayendar Reddy, Y.; Al Temimi, A.H.; Mecinovic, J.
    Fluorinated trimethyllysine as a (19)F NMR probe for trimethyllysine hydroxylase catalysis (2017), Org. Biomol. Chem., 15, 1350-1354 .
    View publication on PubMed
Search for more literature for 1.14.11.8

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on, required for catalysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
 (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NVH6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NMR spectrosopic structure analysis of substrates and products Homo sapiens ?
-
 ?
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens (3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?
N6-fluoromethyl-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 Nepsilon-trimethyllysine analogue that contains the fluoromethyl group can be used as a 1H and 19F NMR probe for studies on TMLH catalysis Homo sapiens (3S)-3-hydroxy-N6-fluoromethyl-N6,N6-dimethyl-L-lysine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
TMLH
-
 Homo sapiens
trimethyllysine hydroxylase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nepsilon-trimethyllysine in the first step of carnitine biosynthesis in humans Homo sapiens
physiological function trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nepsilon-trimethyllysine in the first step of carnitine biosynthesis in humans Homo sapiens