Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
rough endoplasmic reticulum | the enzyme is organized in an enzyme complex formed by prolyl3-hydroxylase 1, cartilage-associated protein, and cyclophilin B | Gallus gallus | 5791 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Gallus gallus | the P3H1-CRTAP-Cyp B complex does not stabilize the collagen triple helix, but does inhibit collgane fibril formation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | Q6JHU8 | - |
- |
Purification (Comment) | Organism |
---|---|
native prolyl 3-hydroxylation complex from embrtyos by ultracentrifugation and gelatin affinity chromatography | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Gallus gallus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitation of binding of the P3H1-CRTAP-Cyp B complex to native type I collagen | Gallus gallus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-proline-[collagen] + O2 | prolyl 3-hydroxylase 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hydroxyproline | Gallus gallus | (S3)-hydroxy-L-proline-[collagen] | - |
? | |
additional information | the P3H1-CRTAP-Cyp B complex does not stabilize the collagen triple helix, but does inhibit collgane fibril formation, overview | Gallus gallus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
prolyl 3-hydroxylase 1 | - |
Gallus gallus |