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Literature summary for 1.14.11.7 extracted from

  • Ishikawa, Y.; Wirz, J.; Vranka, J.A.; Nagata, K.; Baechinger, H.P.
    Biochemical characterization of the prolyl 3-hydroxylase 1 cartilage-associated protein cyclophilin B complex (2009), J. Biol. Chem., 284, 17641-17647.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.7

Localization

Localization Comment Organism GeneOntology No. Textmining
rough endoplasmic reticulum the enzyme is organized in an enzyme complex formed by prolyl3-hydroxylase 1, cartilage-associated protein, and cyclophilin B Gallus gallus 5791
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus the P3H1-CRTAP-Cyp B complex does not stabilize the collagen triple helix, but does inhibit collgane fibril formation, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus Q6JHU8
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Purification (Commentary)

Purification (Comment) Organism
native prolyl 3-hydroxylation complex from embrtyos by ultracentrifugation and gelatin affinity chromatography Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Gallus gallus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 quantitation of binding of the P3H1-CRTAP-Cyp B complex to native type I collagen Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-proline-[collagen] + O2 prolyl 3-hydroxylase 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hydroxyproline Gallus gallus (S3)-hydroxy-L-proline-[collagen]
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 ?
additional information the P3H1-CRTAP-Cyp B complex does not stabilize the collagen triple helix, but does inhibit collgane fibril formation, overview Gallus gallus ?
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 ?

Synonyms

Synonyms Comment Organism
prolyl 3-hydroxylase 1
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 Gallus gallus