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Literature summary for 1.14.11.69 extracted from

  • Wei, J.; Antony, J.; Meng, F.; MacLean, P.; Rhind, R.; Laible, G.; Oback, B.
    KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency (2017), Sci. Rep., 7, 7514 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.69

Organism

Organism UniProt Comment Textmining
Mus musculus Q91VY5
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Source Tissue

Source Tissue Comment Organism Textmining
embryo embryonic fibroblast Mus musculus
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fibroblast embryonic fibroblast Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
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 Mus musculus [histone H3]-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?
[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
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 Mus musculus [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
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 Mus musculus [histone H3]-lysine36 + succinate + formaldehyde + CO2
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 ?

Synonyms

Synonyms Comment Organism
JHDM3B
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 Mus musculus
KDM4B
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 Mus musculus

General Information

General Information Comment Organism
physiological function in mouse embryonic fibroblasts engineered for the inducible expression of KDM4B, upon inducing Kdm4b, H3K9/36me3 levels significantly decrease compared to non-induced controls, and H3K9me1 levels significantly increase, while H3K9me2 and H3K27me3 remain unchanged. Reduced H3K9/36me3 levels are restored after somatic nuclear transfer Mus musculus