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Literature summary for 1.14.11.69 extracted from

  • Liang, C.; Hsu, P.; Chou, D.; Pan, C.; Wang, L.; Huang, W.; Tsai, M.; Lo, W.
    The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1 (2011), Nucleic Acids Res., 39, 4151-4165 .
No PubMed abstract available
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Protein Variants

Protein Variants Comment Organism
H235A catalytically deficient mutant Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P39956
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of Rph1 is required for efficient PHR1 expression and the dissociation of Rph1 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
KDM4
-
 Saccharomyces cerevisiae
Rph1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function overexpression of Rph1 reduces the expression of photoreactivation gene PHR1 and increases UV sensitivity. Rph1 is associated at the upstream repression sequence of PHR1 through zinc-finger domains and is dissociated after UV irradiation. Overexpression of Rph1 and H3K36A mutant reduces histone acetylation at the URS. Protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1 Saccharomyces cerevisiae