Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P39956 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Rph1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | Rph1 is mainly a transcriptional repressor, more than 75% of Rph1-regulated genes show increased expression in the Rph1-deletion mutant. The binding motif 5'-CCCCTWA-3' is overrepresented in the promoters of Rph1-repressed genes. A significant proportion of Rph1-regulated genes respond to DNA damage and environmental stress. Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level. The JmjN domain is important in maintaining protein stability and the repressive effect of Rph1 | Saccharomyces cerevisiae |