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Literature summary for 1.14.11.69 extracted from

  • Ryu, H.; Ahn, S.
    Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation (2014), BMC Biol., 12, 75 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.69

Protein Variants

Protein Variants Comment Organism
additional information generation of a rph1DELTA deletion mutant, phenotype overview Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for catalysis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Saccharomyces cerevisiae
-
 histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Saccharomyces cerevisiae
-
 histone H3 N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P39956
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Saccharomyces cerevisiae histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Saccharomyces cerevisiae histone H3 N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JmjC demethylase
-
 Saccharomyces cerevisiae
Rph1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction changes in RENT component recruitment at NTS regions due to loss of H3 methylases or demethylases Saccharomyces cerevisiae
metabolism different roles of histone H3 methylases in regulating Net1/Sir2 recruitment to rDNA regions and the resultant rDNA silencing. In particular, both H3K4 and H3K79 methylation by Set1 and Dot1 positively regulate rDNA silencing, whereas H3K36 methylation by Set2 has the opposite effect Saccharomyces cerevisiae
physiological function changes in histone H3 lysine methylation levels distinctly regulate rDNA silencing by recruiting different silencing proteins to rDNA, thereby contributing to rDNA silencing and nucleolar organization in yeast. The Rph1/Kdm4 demethylase is a JHDM3/JMJD2 orthologue and has in vivo demethylase activity toward H3K36me3/2. Enzyme Rph1 positively affects transcription Saccharomyces cerevisiae
physiological function Rph1 and Gis1 are reported to regulate the expression of PHR1, a photolyase gene required for the light-dependent repair of pyrimidine dimers. Both demethylases contain two zinc fingers and are damage responsive repressors of PHR1. Rph1 positively affects transcription Saccharomyces cerevisiae