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Literature summary for 1.14.11.69 extracted from

  • Crona, F.; Dahlberg, O.; Lundberg, L.E.; Larsson, J.; Mannervik, M.
    Gene regulation by the lysine demethylase KDM4A in Drosophila (2013), Dev. Biol., 373, 453-463.
    View publication on PubMed
Search for more literature for 1.14.11.69

Cloned(Commentary)

Cloned (Comment) Organism
characterization of dKDM4A alleles, and the dKDM4A genomic locus, the dKDM4A locus contains four exons, overview. Quantitative RT-PCR of dKDM4A expression analysis of wild-type and mutant enzymes in larvae Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
H195A site-directed mutagenesis Drosophila melanogaster
additional information generation of JmjC protein dKDM4A mutant allele, DELTAdKDM4A, with a deletion spanning from 47 nucleotides downstream of the ATG to the end of the gene by means of imprecise excision of the P-element P{GawB}NP0618 Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Drosophila melanogaster 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Drosophila melanogaster KDM4A demethylates H3K36me3, a modification enriched in the 3' end of active genes histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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 gene dkdm4a
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Source Tissue

Source Tissue Comment Organism Textmining
larva quantitative RT-PCRof dKDM4A expression analysis of wild-type and mutant enzymes in larvae Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 KDM4A demethylates H3K36me3, a modification enriched in the 3' end of active genes Drosophila melanogaster histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JmjC protein
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 Drosophila melanogaster
KDM4
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 Drosophila melanogaster
KDM4A demethylase
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction enzyme mutants show 99 misregulated genes in first instar larvae. dKDM4A overexpression results in a global decrease in H3K36me3 levels and male lethality, which might be caused by impaired dosage compensation Drosophila melanogaster
additional information a modest increase in global H3K36me3 levels is compatible with viability, fertility, and the expression of most genes, whereas decreased H3K36me3 levels are detrimental in males Drosophila melanogaster
physiological function identification of dKDM4A-regulated genes, overview. Appropriate expression levels for some dKDM4A-regulated genes rely on the demethylase activity of dKDM4A, whereas others do not. Highly expressed, many demethylase-dependent and independent genes are devoid of H3K36me3 in wild-type as well as in dKDM4A mutant larvae. Some of the most strongly affected genes in dKDM4A mutant animals are not regulated by H3K36 methylation Drosophila melanogaster