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Literature summary for 1.14.11.69 extracted from
- Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation (2007), J. Biol. Chem., 282, 20827-20835.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | overexpression bypasses the requirement for the positive elongation factor gene BUR1 | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2 | Saccharomyces cerevisiae | enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36 | methyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2 | - |
? |  |
| additional information | Saccharomyces cerevisiae | general function of histone demethylase for histone 3 L-lysine 36 is to promote transcription elongation by antagonizing repressive L-lysine 36 methylation by Set2 methyltransferase | ? | - |
? | |
| trimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2 | Saccharomyces cerevisiae | enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36 | dimethyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
isoform Rph1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2 | enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36 | Saccharomyces cerevisiae | methyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
| additional information | general function of histone demethylase for histone 3 L-lysine 36 is to promote transcription elongation by antagonizing repressive L-lysine 36 methylation by Set2 methyltransferase | Saccharomyces cerevisiae | ? | - |
? | |
| trimethyl-histone 3 L-lysine 36 + 2-oxoglutarate + O2 | enzyme Rph1 is specific for di- and trimethyl-histone 3 L-lysine36 | Saccharomyces cerevisiae | dimethyl-histone 3 L-lysine 36 + succinate + formaldehyde + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Rph1 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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