Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | A1L1S9 | isoform Utx1 | - |
Homo sapiens | O15550 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | UTX is enriched around the transcription start sites of many HOX genes in primary human fibroblasts | Homo sapiens | - |
additional information | UTX is selectively excluded from the HOX loci in embryonic stem cells, in which HOX genes are largely silent | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Kdm6al | - |
Danio rerio |
UTX1 | - |
Danio rerio |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition of Utx1 results in misregulation of hox genes and a striking posterior developmental defect, which is partially rescued by wild-type, but not by catalytically inactive, human Utx | Danio rerio |
physiological function | RNAi inhibition of UTX leads to increased H3K27me3 levels at some HOX gene promoters | Homo sapiens |