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Literature summary for 1.14.11.68 extracted from
- Histone H3 lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation (2015), Nat. Commun., 6, 8152 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q5NCY0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymocyte | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | both demthylase Utx and Jmjd3 redundantly promote H3K27Me3 removal at, and expression of, a specific subset of genes involved in terminal thymocyte differentiation, especially S1pr1, encoding a sphingosine-phosphate receptor required for thymocyte egress. Thymocyte expression of S1pr1 is not rescued in Jmjd3- and Utx-deficient male mice, which carry the catalytically inactive Utx homolog Uty | Mus musculus |
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Release 2023.1 (January 2023)
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