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Literature summary for 1.14.11.68 extracted from

  • Messer, H.G.; Jacobs, D.; Dhummakupt, A.; Bloom, D.C.
    Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons (2015), J. Virol., 89, 3417-3420 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine inhibition of JMJD3 and UTX blocks reactivation-induced H3K27me3 demethylation of herpes simplex virus genomes Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
GSK-J4 specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits herpes simplex virus HSV-1 reactivation from sensory neurons in vitro; specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits herpes simplex virus HSV-1 reactivation from sensory neurons in vitro Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O70546
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Mus musculus Q5NCY0
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Source Tissue

Source Tissue Comment Organism Textmining
neuron primary adult murine trigeminal ganglion neuron Mus musculus
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