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Literature summary for 1.14.11.68 extracted from

  • Liu, Z.; Cao, W.; Xu, L.; Chen, X.; Zhan, Y.; Yang, Q.; Liu, S.; Chen, P.; Jiang, Y.; Sun, X.; Tao, Y.; Hu, Y.; Li, C.; Wang, Q.; Wang, Y.; Chen, C.D.; Shi, Y.; Zhang, X.
    The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation (2015), J. Mol. Cell Biol., 7, 505-516 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
GSK-J4 specific inhibitor, application dramatically suppresses Th17 cell differentiation in vitro Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q5NCY0
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General Information

General Information Comment Organism
physiological function histone H3 lysine-27 demethylation crucially regulatesT helper cell Th17 differentiation. Activation of naive CD41 T cells immediately induces high expression of Jmjd3. Genetic depletion of Jmjd3 in CD41 T cells specifically impairs Th17 cell differentiation both in vitro and in vivo. Jmjd3-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis. Inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppresses Th17 cell differentiation in vitro. Jmjd3 directly binds to and reduces the level of H3K27 trimethylation (me3) at the genomic sites of Rorc Mus musculus