Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15054 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histine H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2 | - |
Homo sapiens | a [histine H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | JMJD3 is associated with demethylase KIAA1718. JMJD3 and KIAA1718 directly bind to and regulate the expression of a plethora of common target genes in both a demethylase activity-dependent and -independent manner. JMJD3 and KIAA1718 collaborate to demethylate trimethylated H3K27 (H3K27me3) on a subset of their target genes. Reduction of either JMJD3 or KIAA1718 diminishes polymerase Pol II traveling along the gene bodies of the affected genes while having no effect on the promoter-proximal Pol II. JMJD3 and KIAA1718 also play a role in localizing elongation factors SPT6 and SPT16 to the target genes | Homo sapiens |