Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.68 extracted from

  • Seenundun, S.; Rampalli, S.; Liu, Q.C.; Aziz, A.; Palii, C.; Hong, S.; Blais, A.; Brand, M.; Ge, K.; Dilworth, F.J.
    UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis (2010), EMBO J., 29, 1401-1411 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.68

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus O70546
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function demethylase UTX mediates removal of H3K27me3 at the Myog and CKm genes. Transactivator Six4 initially recruits UTX to the regulatory region of muscle genes. The resulting loss of H3K27me3 marks is limited to the region upstream of the transcriptional start site. Blocking polymerase Pol II elongation on transcribed genes leads to increased H3K27me3 within the coding region, and formation of bivalent (H3K27me3/H3K4me3) chromatin domains Mus musculus