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Literature summary for 1.14.11.67 extracted from

  • Shen, Y.; Conde E Silva, N.; Audonnet, L.; Servet, C.; Wei, W.; Zhou, D.X.
    Over-expression of histone H3K4 demethylase gene JMJ15 enhances salt tolerance in Arabidopsis (2014), Front. Plant Sci., 5, 290 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene JMJ15, quantitative RT-PCR enzyme expression analysis, pJMJ15-GUS and 35S-JMJ15-FLAG-HA constructs are transformed into Agrobacterium tumefaciens strain GV3101 and then transformed into plants using the floral dip method Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information construction of JMJ15 T-DNA insertion mutants, phenotypes, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Arabidopsis thaliana 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Arabidopsis thaliana
-
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Arabidopsis thaliana Col-0
-
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O64752
-
-
Arabidopsis thaliana Col-0 O64752
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
Arabidopsis thaliana
-
additional information expression of gene JMJ15 is relatively low and is limited to a number of tissues during vegetative growth but is higher in young floral organs. JMJ15 displays a highly tissue-specific expression pattern Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Arabidopsis thaliana histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 specific for Arabidopsis thaliana histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Arabidopsis thaliana Col-0 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 specific for Arabidopsis thaliana Col-0 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
additional information the enzyme shows no activity with histone H3 N6,N6-dimethyl-L-lysine4 and histone H3 N6-methyl-L-lysine4 Arabidopsis thaliana ?
-
?
additional information the enzyme shows no activity with histone H3 N6,N6-dimethyl-L-lysine4 and histone H3 N6-methyl-L-lysine4 Arabidopsis thaliana Col-0 ?
-
?

Synonyms

Synonyms Comment Organism
At2g34880
-
Arabidopsis thaliana
H3K4 demethylase
-
Arabidopsis thaliana
histone H3K4 demethylase
-
Arabidopsis thaliana
JMJ15
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction overexpression of the gene in gain-of-function mutants reduces the plant height with accumulation of lignin in stems, while the loss-of-function mutation does not produce any visible phenotype. The gain-of-function mutants show enhanced salt tolerance, whereas the loss-of-function mutant is more sensitive to salt compared to the wild-type. Overexpression of JMJ15 downregulates many genes which are preferentially marked by H3K4me3 and H3K4me2. Many of the downregulated genes encode transcription regulators involved in stress responses Arabidopsis thaliana
physiological function histone lysine methylation is an important epigenetic modification for gene expression in eukaryotic cells. Increased JMJ15 levels may regulate the gene expression program that enhances stress tolerance Arabidopsis thaliana