Cloned (Comment) | Organism |
---|---|
gene JMJ15, quantitative RT-PCR enzyme expression analysis, pJMJ15-GUS and 35S-JMJ15-FLAG-HA constructs are transformed into Agrobacterium tumefaciens strain GV3101 and then transformed into plants using the floral dip method | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of JMJ15 T-DNA insertion mutants, phenotypes, overview | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Arabidopsis thaliana | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | Arabidopsis thaliana | - |
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | Arabidopsis thaliana Col-0 | - |
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | O64752 | - |
- |
Arabidopsis thaliana Col-0 | O64752 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
flower | - |
Arabidopsis thaliana | - |
additional information | expression of gene JMJ15 is relatively low and is limited to a number of tissues during vegetative growth but is higher in young floral organs. JMJ15 displays a highly tissue-specific expression pattern | Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana | histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | specific for | Arabidopsis thaliana | histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana Col-0 | histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | specific for | Arabidopsis thaliana Col-0 | histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
additional information | the enzyme shows no activity with histone H3 N6,N6-dimethyl-L-lysine4 and histone H3 N6-methyl-L-lysine4 | Arabidopsis thaliana | ? | - |
? | |
additional information | the enzyme shows no activity with histone H3 N6,N6-dimethyl-L-lysine4 and histone H3 N6-methyl-L-lysine4 | Arabidopsis thaliana Col-0 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
At2g34880 | - |
Arabidopsis thaliana |
H3K4 demethylase | - |
Arabidopsis thaliana |
histone H3K4 demethylase | - |
Arabidopsis thaliana |
JMJ15 | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of the gene in gain-of-function mutants reduces the plant height with accumulation of lignin in stems, while the loss-of-function mutation does not produce any visible phenotype. The gain-of-function mutants show enhanced salt tolerance, whereas the loss-of-function mutant is more sensitive to salt compared to the wild-type. Overexpression of JMJ15 downregulates many genes which are preferentially marked by H3K4me3 and H3K4me2. Many of the downregulated genes encode transcription regulators involved in stress responses | Arabidopsis thaliana |
physiological function | histone lysine methylation is an important epigenetic modification for gene expression in eukaryotic cells. Increased JMJ15 levels may regulate the gene expression program that enhances stress tolerance | Arabidopsis thaliana |