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Literature summary for 1.14.11.67 extracted from

  • Maina, P.K.; Shao, P.; Jia, X.; Liu, Q.; Umesalma, S.; Marin, M.; Long, D.; Concepcion-Roman, S.; Qi, H.H.
    Histone demethylase PHF8 regulates hypoxia signaling through HIF1alpha and H3K4me3 (2017), Biochim. Biophys. Acta, 1860, 1002-1012 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.67

Protein Variants

Protein Variants Comment Organism
F279S catalytically lethal mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 Homo sapiens overall reaction [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CWR22-Rv1 cell
-
 Homo sapiens
-
DU-145 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
LNCaP-Abl cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
Phoenix-AMPHO cell
-
 Homo sapiens
-
RWPE-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 overall reaction Homo sapiens [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PHD finger protein 8
-
 Homo sapiens
PHF8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays an essential role in hypoxia signaling. The enzyme regulates the expression of hypoxia-induced neuroendocrine differentiation genes. The enzyme is essential for maintaining [histone H3]-N6,N6,N6-trimethyl-L-lysine4 levels on hypoxia-inducible genes. In the context of prostate cancer, the enzyme appears to execute its regulatory function during hypoxia signaling in androgen receptor-positive prostate cancer cells Homo sapiens