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Literature summary for 1.14.11.67 extracted from

  • Lopez-Bigas, N.; Kisiel, T.; DeWaal, D.; Holmes, K.; Volkert, T.; Gupta, S.; Love, J.; Murray, H.; Young, R.; Benevolenskaya, E.
    Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation (2008), Mol. Cell, 31, 520-530.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
RBP2, gene expression profiling and computational analyses of gene targeting Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
nucleus
-
 Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RB-binding protein 2, RBP2, is a key effector for retinoblastoma protein mediating cell-cycle withdrawal and differentiation by interacting with a variety of proteins. During differentiation, RBP2 exerts inhibitory effects on multiple genes through direct interaction with their promoters. RBP2 shows high correlation with the presence of H3K4me3, and its target genes are separated into two functionally distinct classes: differentiation-independent and differentiation-dependent genes. Molecular mechanisms of RBP2 regulation of differentiation, overview. Functional analysis of RBP2 target genes and differentially expressed genes, overview ?
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 Homo sapiens recruitment of RBP2 to the promoter region of a key mitochondrial component results in demethylation of H3K4 at this promoter and its transcriptional repression [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RB-binding protein 2, RBP2, is a key effector for retinoblastoma protein mediating cell-cycle withdrawal and differentiation by interacting with a variety of proteins. During differentiation, RBP2 exerts inhibitory effects on multiple genes through direct interaction with their promoters. RBP2 shows high correlation with the presence of H3K4me3, and its target genes are separated into two functionally distinct classes: differentiation-independent and differentiation-dependent genes. Molecular mechanisms of RBP2 regulation of differentiation, overview. Functional analysis of RBP2 target genes and differentially expressed genes, overview Homo sapiens ?
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2
-
 Homo sapiens [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 recruitment of RBP2 to the promoter region of a key mitochondrial component results in demethylation of H3K4 at this promoter and its transcriptional repression Homo sapiens [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?

Synonyms

Synonyms Comment Organism
H3K4 histone demethylase
-
 Homo sapiens
RB-binding protein 2
-
 Homo sapiens
RBP2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function role of RBP2 in mitochondrial biogenesis, which involves regulation of H3K4me3-modified nucleosomes Homo sapiens