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Literature summary for 1.14.11.66 extracted from

  • Tsurumi, A.; Dutta, P.; Dutta, P.; Shang, R.; Yan, S.J.; Sheng, R.; Li, W.X.
    Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling (2013), Sci. Rep., 3, 2894 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster overall reaction [histone H3]-N6-methyl-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
-
 [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster overall reaction [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Drosophila melanogaster
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
-
 [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Drosophila melanogaster
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Drosophila melanogaster
-
salivary gland
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 overall reaction Drosophila melanogaster [histone H3]-N6-methyl-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Drosophila melanogaster [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Drosophila melanogaster [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 57000, Flag-tagged enzyme, SDS-PAGE Drosophila melanogaster

Synonyms

Synonyms Comment Organism
JMJD2(1)
-
 Drosophila melanogaster
JMJD2(2)
-
 Drosophila melanogaster
KDM4A isoform Drosophila melanogaster
KDM4B isoform Drosophila melanogaster

General Information

General Information Comment Organism
malfunction enzyme loss leads to globally elevated levels of the heterochromatin marker [histone H3]-N6,N6-dimethyl-L-lysine9/[histone H3]-N6,N6,N6-trimethyl-L-lysine9 and impedes transcriptional activation of ecdysone response genes, resulting in developmental arrest. Drosophila melanogaster
physiological function isoforms Kdm4A and Kdm4B are together essential for mediating ecdysteroid hormone signaling during larval development Drosophila melanogaster