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Literature summary for 1.14.11.66 extracted from

  • Tateishi, K.; Okada, Y.; Kallin, E.; Zhang, Y.
    Role of Jhdm2a in regulating metabolic gene expression and obesity resistance (2009), Nature, 458, 757-761 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PCM1
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-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
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 Mus musculus
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skeletal muscle
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 Mus musculus
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Synonyms

Synonyms Comment Organism
H3K9-specific demethylase
-
 Mus musculus
JHDM2A
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 Mus musculus
JMJD1A
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 Mus musculus
Kdm3a
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is induced by beta-adrenergic stimulation up

General Information

General Information Comment Organism
malfunction loss of enzyme function results in obesity and hyperlipidemia in mice. Loss of enzyme function disrupts beta-adrenergic-stimulated glycerol release and oxygen consumption in brown fat, and decreases fat oxidation and glycerol release in skeletal muscles Mus musculus
physiological function the enzyme plays an essential role in regulating metabolic gene expression and normal weight control in mice. The enzyme directly regulates peroxisome proliferator-activated receptor alpha and Ucp1 expression Mus musculus