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Literature summary for 1.14.11.66 extracted from

  • Li, W.; Zhao, L.; Zang, W.; Liu, Z.; Chen, L.; Liu, T.; Xu, D.; Jia, J.
    Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer (2011), Biochem. Biophys. Res. Commun., 416, 372-378 .
No PubMed abstract available
Search for more literature for 1.14.11.66

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM4B or Jmjd2b, real-time quantitative PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information Jmjd2b knockdown by siRNA, leading to induction of p53 via activation of the DNA damage response pathway. p53 Inhibition significantly restored the clonogenic potential of AGS and HeLa cells treated with JMJD2B siRNA. Increased apoptosis in BGC-823 and HeLa cells but not AGS cells with JMJD2B siRNA knockdown. AGS cells are arrested at the G1 phase, but BGC-823 and HeLa cells are arrested at the S phase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O94953
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
BGC-823 cell
-
 Homo sapiens
-
carcinoma cell
-
 Homo sapiens
-
gastric cancer cell JMJD2B expression profile in gastric cancer, overview Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
HGC-27 cell
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional enzyme specifically demethylates Lys9 and Lys36 (EC 1.14.11.69) residues of histone H3 Homo sapiens ?
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JMJD2B
-
 Homo sapiens
KDM4B
-
 Homo sapiens
More see also for EC 1.14.11.69 Homo sapiens

General Information

General Information Comment Organism
malfunction knocking down JMJD2B expression by siRNA in gastric and other cancer cells inhibits cell proliferation and/or induces apoptosis and elevates the expression of p53 and p21CIP1 proteins, mechanism of JMJD2B inhibition, overview. The enhanced p53 expression results from activation of the DNA damage response pathway Homo sapiens
physiological function histone demethylase JMJD2B regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 9 on histone H3 and is required for tumor cell proliferation and survival in vitro and in vivo, and is overexpressed in gastric cancer Homo sapiens