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Literature summary for 1.14.11.66 extracted from

  • Yuan, X.; Kong, J.; Ma, Z.; Li, N.; Jia, R.; Liu, Y.; Zhou, F.; Zhan, Q.; Liu, G.; Gao, S.
    KDM4C, a H3K9me3 histone demethylase, is involved in the maintenance of human ESCC-initiating cells by epigenetically enhancing SOX2 expression (2016), Neoplasia, 18, 594-609 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Inhibitors

Inhibitors Comment Organism Structure
caffeic acid a KDM4C inhibitor, that preferentially abolishes tumor-initiating cells in an ALDHbri+-derived xenograft model in vivo Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin
-
 Homo sapiens 785
-
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H3R0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EC-9706 cell
-
 Homo sapiens
-
esophageal squamous cell carcinoma cell the histone demethylase KDM4C is enhanced in ALDHbri+ subpopulation, a subpopulation of cells isolated from esophageal squamous cell carcinoma (ESCC) patient-derived tumor specimens marked by an ALDHbri+ phenotype bear stem cell-like features Homo sapiens
-
KYSE-150 cell
-
 Homo sapiens
-
KYSE-30 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional enzyme specifically demethylates Lys9 (H3K9me3/me2) and Lys36 (H3K36me3/me2, EC 1.14.11.69) residues of histone H3 Homo sapiens ?
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GASC1
-
 Homo sapiens
H3K9me3 histone demethylase
-
 Homo sapiens
JMJD2C
-
 Homo sapiens
Kdm4c
-
 Homo sapiens

General Information

General Information Comment Organism
evolution KDM4C is a member of the KDM4 subgroup of JmjC domain-containing proteins which catalyzes the demethylation of tri- and dimethylated lysine 9 and lysine 36 on histoneH3 Homo sapiens
physiological function KDM4C acts as an oncogene that is amplifiedin esophageal cancer cell line, KYSE-150. Role of the KDM4C in the maintenance of tumor-initiating cells (TICs) in esophageal squamous cell carcinoma (ESCC). The cytoplasmic and nuclear KDM4C staining increased with adverse pathologic phenotypes and poor patient survival. KDM4C blockade selectively decreases the ESCC ALDHbri+ TICs population in vitro and specifically targets the TICs in ALDHbri+-derived xenograft, retarding engraftment. Subsequent studies of the KDM4C functional network identified a subset of pluripotency-associated genes (PAGs) and aldehyde dehydrogenase family members to be preferentially downregulated in KDM4C-inhibited ALDHbri+ TICs. KDM4C maintains permissive histone modifications with a low level of H3K9 methylation at the promoters of several PAGs Homo sapiens