Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Kdm3b knockout (Kdm3bKO) mice, phenotype, overview. female Kdm3bKO mice exhibit a severely impaired reproductive function, knockout of Kdm3b increases the levels of H3K9me1, H3K9me2 and H3K9me3 in the ovary and uterus. Knockout of Kdm3b in female mice prolonges their estrous cycles and reduces their ovulation capacity and fertilization efficiency | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus | - |
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus C57BL/6 | - |
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus | - |
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus C57BL/6 | - |
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus | - |
histone H3 L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | Mus musculus C57BL/6 | - |
histone H3 L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6ZPY7 | - |
- |
Mus musculus C57BL/6 | Q6ZPY7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | Kdm3b is highly expressed in the female reproductive organs including ovary, oviduct and uterus | Mus musculus | - |
ovary | - |
Mus musculus | - |
oviduct | - |
Mus musculus | - |
uterus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus | histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus C57BL/6 | histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus | histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus C57BL/6 | histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus | histone H3 L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Mus musculus C57BL/6 | histone H3 L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5qNCA | - |
Mus musculus |
histone H3K9 demethylase | - |
Mus musculus |
JHDM2B | - |
Mus musculus |
JMJD1B | - |
Mus musculus |
Kdm3b | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Kdm3b knockout mice show restricted postnatal growth and female infertility. Kdm3b ablation decreases IGFBP-3 expressed in the kidney by 53% and significantly reduces IGFBP-3 in the blood, which causes an accelerated degradation of IGF-1 and a 36% decrease in circulating IGF-1 concentration. Kdm3b is highly expressed in the female reproductive organs including ovary, oviduct and uterus. Knockout of Kdm3b in female mice causes irregular estrous cycles, decreases 45% of the ovulation capability and 47% of the fertilization rate, and reduces 44% of the uterine decidual response, which are accompanied with a more than 50% decrease in the circulating levels of the 17beta-estradiol. These female reproductive phenotypes are associated with significantly increased levels of H3K9me1/2/3 in the ovary and uterus. Kdm3bKO mice exhibit restricted somatic growth, low levels of circulating IGF-1 and IGFBP-3 and fast degradation of IGF-1. Female Kdm3bKO mice exhibit a severely impaired reproductive function. Knockout of Kdm3b in female mice prolonges their estrous cycles and reduces their ovulation capacity and fertilization efficiency. Phenotype, overview | Mus musculus |
additional information | the enzyme contains a Jumonji C (JmjC) domain | Mus musculus |
physiological function | enzyme Kdm3b is a Jumonji C domain-containing protein that demethylates mono- and dimethylated lysine 9 of histone H3 (H3K9me1 and H3K9me2). Kdm3b-mediated H3K9 demethylation plays essential roles in maintenance of the circulating IGF-1, postnatal somatic growth, circulating 17beta-estradiol, and female reproductive function | Mus musculus |