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Literature summary for 1.14.11.66 extracted from

  • Verrier, L.; Escaffit, F.; Chailleux, C.; Trouche, D.; Vandromme, M.
    A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation (2011), PLoS Genet., 7, e1001390.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
short isoform of JMJD2A expression analysis, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA silencing of DELTAN-JMJD2A results in drastic impairment of MHC expression and myotube formation, the Myog promoter is a specific target of DElTAN-JMJD2A. Genome-wide expression profiling and exon-specific siRNA knockdown indicate that, in contrast to the full-length protein, N-terminal demethylase domainis necessary for myotube formation and muscle-specific gene expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle short isoform of JMJD2A is upregulated during muscle differentiation, expression analysis and pattern, overview Homo sapiens
-
myotube
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone demethylase
-
 Homo sapiens
JMJD2A/KDM4A
-
 Homo sapiens
Jumonji domaincontaining demethylase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens short isoform of JMJD2A is upregulated during muscle differentiation up

General Information

General Information Comment Organism
evolution the enzyme belongs to the JMJD2/KDM4 subfamily (JMJD2A, B, C and D) specifically demethylates H3K9 and H3K36 either di- or trimethylated Homo sapiens
physiological function Derepression of the promoter of the gene encoding the myogenic factor myogenin (Myog) is key for initiation of muscle differentiation, mechanism of H3K9 demethylation at the Myog promoter, overview. Genome-wide expression profiling and exon-specific siRNA knockdown indicate that, in contrast to the full-length protein, N-terminal demethylase domainis necessary for myotube formation and muscle-specific gene expression. promotes MyoD-induced conversion of NIH3T3 cells into muscle cells. ChIP-on-chip analysis indicates that DN-JMJD2A binds to genes mainly involved in transcriptional control and that this binding is linked to gene activation. DN-JMJD2A is recruited to the Myog promoter at the onset of differentiation. This binding is essential to promote the demethylation of H3K9me2 and H3K9me3 Homo sapiens