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Literature summary for 1.14.11.66 extracted from

  • Yang, J.; Jubb, A.M.; Pike, L.; Buffa, F.M.; Turley, H.; Baban, D.; Leek, R.; Gatter, K.C.; Ragoussis, J.; Harris, A.L.
    The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth (2010), Cancer Res., 70, 6456-6466.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine histone demethylase JMJD2B is a therapeutic target in breast cancer patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
JMJD2B quantitative RT-PCR expression analysis, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-361 cell
-
 Homo sapiens
-
MDA-MB-468 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
histone demethylase JMJD2B
-
 Homo sapiens
JMJD2B
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens estrogen receptor alpha is important for JMJD2B expression in hypoxia, JMJD2B can be upregulated in hypoxia in an HIF-1alpha-dependent manner up

General Information

General Information Comment Organism
additional information JMJD2B is important for breast cancer cell proliferation. JMJD2B and the hypoxia marker CA9 together stratify a subclass of breast cancer patients and predict a worse outcome of these breast cancers Homo sapiens
physiological function JMJD2B regulates multiple biological processes including the cell cycle. The histone demethylase JMJD2B is regulated by both estrogen receptor alpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1. Histone demethylase function of JMJD2B in hypoxia, overview Homo sapiens