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Literature summary for 1.14.11.66 extracted from

  • Brasacchio, D.; Okabe, J.; Tikellis, C.; Balcerczyk, A.; George, P.; Baker, E.K.; Calkin, A.C.; Brownlee, M.; Cooper, M.E.; El-Osta, A.
    Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail (2009), Diabetes, 58, 1229-1236.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Activating Compound

Activating Compound Comment Organism Structure
additional information transient hyperglycemia induces recruitment of LSD1 to gene regulation sites/promoters Mus musculus
additional information transient hyperglycemia induces recruitment of LSD1 to gene regulation sites/promoters Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus LSD1 is a nuclear amine oxidase that utilizes oxygen as an electron acceptor to reduce methylated lysine to form lysine. It demethylates H3K4m1 and H3K4m2, as well as H3K9m1 and H3K9m2 as a removal of the active nethylation mark ?
-
 ?
additional information Homo sapiens LSD1 is a nuclear amine oxidase that utilizes oxygen as an electron acceptor to reduce methylated lysine to form lysine. It demethylates H3K4m1 and H3K4m2, as well as H3K9m1 and H3K9m2 as a removal of the active nethylation mark ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Mus musculus
-
 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Homo sapiens
-
 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Mus musculus
-
 [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Homo sapiens
-
 [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta of control and hyperglycemic mice Mus musculus
-
vascular cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LSD1 is a nuclear amine oxidase that utilizes oxygen as an electron acceptor to reduce methylated lysine to form lysine. It demethylates H3K4m1 and H3K4m2, as well as H3K9m1 and H3K9m2 as a removal of the active nethylation mark Mus musculus ?
-
 ?
additional information LSD1 is a nuclear amine oxidase that utilizes oxygen as an electron acceptor to reduce methylated lysine to form lysine. It demethylates H3K4m1 and H3K4m2, as well as H3K9m1 and H3K9m2 as a removal of the active nethylation mark Homo sapiens ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Mus musculus [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
 Mus musculus [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

Synonyms Comment Organism
LSD1
-
 Mus musculus
LSD1
-
 Homo sapiens
LSD1 demethylase
-
 Mus musculus
LSD1 demethylase
-
 Homo sapiens
LSD1 H3 demethylase
-
 Mus musculus
LSD1 H3 demethylase
-
 Homo sapiens
lysine-specific demethylase 1
-
 Mus musculus
lysine-specific demethylase 1
-
 Homo sapiens
More the enzyme belongs to the Jumonji C, JmjC, protein family, that is specific for the demethylation of H3K9me1/2 Mus musculus
More the enzyme belongs to the Jumonji C, JmjC, protein family, that is specific for the demethylation of H3K9me1/2 Homo sapiens

General Information

General Information Comment Organism
physiological function LSD1 is associated with co-repressor complexes and promotes suppression or activation of gene expression, e.g. LSD1 might be associated to cooperative recruitment to the NFkappaB p65 site for activation in hyperglycemia Mus musculus
physiological function LSD1 is associated with co-repressor complexes and promotes suppression or activation of gene expression, e.g. LSD1 might be associated to cooperative recruitment to the NFkappaB p65 site for activation in hyperglycemia Homo sapiens