Crystallization (Comment) | Organism |
---|---|
structures of JMJD2A-Ni(II)-Zn(II) inhibitor complexes bound to tri-, di- and monomethyl forms of histone 3 lysine 9 and the trimethyl form of histone 3 lysine 36. The structures reveal a lysyl-binding pocket in which substrates are bound in distinct bent conformations involving the Zn-binding site. The mechansim for achieving methylation state selectivity involves the orientation of the substrate methyl groups towards a ferryl intermediate | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | the mechansim for achieving methylation state selectivity involves the orientation of the substrate methyl groups towards a ferryl intermediate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75164 | isoform JMJD2A | - |
Synonyms | Comment | Organism |
---|---|---|
JMJD2A | - |
Homo sapiens |