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Literature summary for 1.14.11.65 extracted from

  • Fan, L.; Peng, G.; Sahgal, N.; Fazli, L.; Gleave, M.; Zhang, Y.; Hussain, A.; Qi, J.
    Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival (2015), Oncogene, 35, 2441-2452 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4C1
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-

Source Tissue

Source Tissue Comment Organism Textmining
CWR22-Rv1 cell
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 Homo sapiens
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DU-145 cell
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 Homo sapiens
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LNCaP cell
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 Homo sapiens
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PC-3 cell
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 Homo sapiens
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prostate gland
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
JMJD1A
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 Homo sapiens

General Information

General Information Comment Organism
physiological function JMJD1A knockdown in prostate cancer cells antagonizes their proliferation and survival. JMJD1A-dependent genes function in cellular growth, proliferation and survival, JMJD1A enhances c-Myc transcriptional activity by upregulating c-Myc expression levels. JMJD1A activity promotes recruitment of androgen receptor (AR) to the c-Myc gene enhancer and induces H3K9 demethylation, increasing AR-dependent transcription of c-Myc mRNA. JMJD1A regulates c-Myc stability, likely by inhibiting HUWE1. JMJD1A binds to HUWE1, attenuates HUWE1-dependent ubiquitination and subsequent degradation of c-Myc, increasing c-Myc protein levels Homo sapiens