Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.65 extracted from

  • Qi, H.; Sarkissian, M.; Hu, G.; Wang, Z.; Bhattacharjee, A.; Gordon, D.; Gonzales, M.; Lan, F.; Ongusaha, P.; Huarte, M.; Yaghi, N.; Lim, H.; Garcia, B.; Brizuela, L.; Zhao, K.; Roberts, T.; Shi, Y.
    Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development (2010), Nature, 466, 503-507 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
F279S mutation identified in patients with X-linked mental retardation. abolishes catalytic activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Danio rerio P0CH95
-
-
Homo sapiens Q9UPP1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
jaw
-
Danio rerio
-
neuron
-
Danio rerio
-
U2-OS cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
Homo sapiens a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
?
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
Danio rerio a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
?
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
Homo sapiens a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
?
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
Danio rerio a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
?
additional information enzyme acts additionally as mono-methyl histone H4 lysine 20 demethylase Homo sapiens ?
-
?
additional information enzyme acts additionally as mono-methyl histone H4 lysine 20 demethylase Danio rerio ?
-
?

Synonyms

Synonyms Comment Organism
histone lysine demethylase
-
Danio rerio
PHF8
-
Homo sapiens
PHF8
-
Danio rerio

General Information

General Information Comment Organism
physiological function PHF8 over-expression in U2OS but not HeLa cells results in a significant reduction of H3K9me2 level and only a slight reduction of the global level of H4K20me1 Homo sapiens
physiological function PHF8 regulates cell survival in the zebrafish developing brain and jaw development. In a model PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB Danio rerio