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Literature summary for 1.14.11.65 extracted from

  • Loh, Y.H.; Zhang, W.; Chen, X.; George, J.; Ng, H.H.
    Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells (2007), Genes Dev., 21, 254525-57 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PCM1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
JMJD1A
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus expression is positively regulated by the embryonic stem cell transcription factor Oct4 up

General Information

General Information Comment Organism
physiological function Jmjd1a depletion leads to embryonic stem cell differentiation, which is accompanied by a reduction in the expression of embryonic stem cell-specific genes and an induction of lineage marker genes. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes Mus musculus