Protein Variants | Comment | Organism |
---|---|---|
F279S | mutation identified in X-linked mental retardation patients, mutant is defective in enzymatic activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UPP1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
additional information | PHF8 exhibits both H3K4 and H3K9 demethylase activity in cells, but recombinant PHF8 exhibits only H3K9me2/1 demethylase activity in vitro | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHF8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PHF8 binds specifically to H3K4me3/2 peptides via an N-terminal PHD finger domain. Knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs retinoic acid-induced neuronal differentiation, whereas overexpression of PHF8 drives P19 cells toward neuronal differentiation. PHF8 interacts with retinoic acid receptor alpha and functions as a coactivator | Homo sapiens |