Protein Variants | Comment | Organism |
---|---|---|
H1560A/D1562A/H1689A | catalytically inactive mutant, carries mutations in the conserved cofactor (Fe2+) binding site | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme additionally mediates arginine demethylation of H4R3me2s and its intermediate, H4R3me1. Demethylation of H4R3me2s and H3K9me2s in promoter regions is correlated with active gene expression | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JMJD1B | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | knockout of JMJD1B blocks demethylation of H4R3me2s and/or H3K9me2 at distinct clusters of genes and impairs the activation of genes important for hematopoietic stem/progenitor cell differentiation and development. JMJD1B-/- mice show defects in hematopoiesis | Mus musculus |