Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.65 extracted from

  • Yamane, K.; Toumazou, C.; Tsukada, Y.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y.
    JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor (2006), Cell, 125, 483-95 .
    View publication on PubMed
Search for more literature for 1.14.11.65

Activating Compound

Activating Compound Comment Organism Structure
ascorbate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
300000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Homo sapiens
-
 a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4C1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
JHDM2A
-
 Homo sapiens
lysine-specific demethylase 3A
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme specifically demethylates mono- and dimethyl-histone 3 at residue K9. A JmjC domain and a zinc finger present in JHDM2A are required for its enzymatic activity. Overexpression of JHDM2A greatly reduces the H3K9 methylation level in vivo. Knockdown of JHDM2A results in an increase in the dimethyl-K9 levels at the promoter region of a subset of genes concomitant with decrease in their expression. JHDM2A exhibits hormone-dependent recruitment to androgen-receptor target genes, resulting in H3K9 demethylation and transcriptional activation Homo sapiens