Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.65 extracted from

  • Qin, L.; Xu, Y.; Yu, X.; Toneff, M.; Li, D.; Liao, L.; Martinez, J.; Li, Y.; Xu, J.
    The histone demethylase Kdm3a is required for normal epithelial proliferation ductal elongation and tumor growth in the mouse mammary gland (2017), Oncotarget, 8, 84761-84775 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.65

Activating Compound

Activating Compound Comment Organism Structure
ascorbate
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of Kdm3a knockout mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for catalysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
 histone H3 L-lysine9 + succinate + formaldehyde + CO2
-
 ?
additional information Mus musculus Kdm3a can specifically remove mono- or di-methyl residues from H3K9me1 or H3K9me2 to regulate gene transcription ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PCM1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Mus musculus
-
mammary gland the enzyme is mainly distributed in luminal epithelial cells of wild-type mammary glands Mus musculus
-
additional information Kdm3a protein is differentially expressed in the luminal epithelial cells of mouse mammary glands at different ages Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus histone H3 L-lysine9 + succinate + formaldehyde + CO2
-
 ?
additional information Kdm3a can specifically remove mono- or di-methyl residues from H3K9me1 or H3K9me2 to regulate gene transcription Mus musculus ?
-
 ?
additional information no activity with histone H3 N6,N6,N6-trimethyl-L-lysine9 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
histone demethylase
-
 Mus musculus
Kdm3a
-
 Mus musculus

General Information

General Information Comment Organism
evolution KDM3A is a histone demethylase in the JmjC domain-containing protein family Mus musculus
malfunction knockout of Kdm3a increases H3K9me1 and H3K9me2 in the mammary epithelial cells. Knockout of Kdm3a results in retarded mammary gland ductal growth. Comparison of mammary gland ductal morphogenesis in wild-type and Kdm3a knockout virgin mice, overview. Kdm3a knockout shows no obvious effect on mammary gland tumor initiation but significantly reduces tumor growth Mus musculus
physiological function histone modification alters chromatin architecture to regulate gene transcription. It removes di- and mono-methyl residues from di- or mono-methylated lysine 9 of histone H3 (H3K9me2/me1). Histone demethylase Kdm3a is required for normal epithelial proliferation ductal elongation and tumor growth in the mouse mammary gland. Kdm3a is not required for estrogen-induced ductal growth in the mammary gland. Kdm3a is required for normal proliferation and cyclin D1 expression in the mammary gland epithelial cells during the pubertal fast growing phase of mammary gland development. Kdm3a plays a direct role in upregulating cyclin D1 expression Mus musculus