Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme disruption mutant, and expression of a fusion protein consisting of the first 506 amino acids of the enzyme fused to a beta-galactosidase/neomycin cassette. The fusion protein lacks the catalytic domain. Presence of the active enzyme is essential for spermatogenesis. Mutant mice exhibit post-meiotic chromatin condensation defects. The enzyme binds directly to and controls the expression of transition nuclear protein 1 and protamine genes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6PCM1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spermatid | protein level is the highest in round spermatids, compared with spermatocyte and elogating spermatids | Mus musculus | - |
spermatocyte | protein level is the highest in round spermatids, compared with spermatocyte and elongating spermatids. Protein is not detectable in spermatogonia or gamma-H2AX-positive early pachytene spermatocytes | Mus musculus | - |
testis | high expression at both mRNA and protein level, significant increase during spermatogenesis. Expression during and after meiosis, preceding the expression of transition proteins and protamines | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
JHDM2A | - |
Mus musculus |
JmjC-domain-containing histone demethylase 2A | - |
Mus musculus |
JMJD1A | - |
Mus musculus |