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Literature summary for 1.14.11.65 extracted from

  • Okada, Y.; Scott, G.; Ray, M.K.; Mishina, Y.; Zhang, Y.
    Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis (2007), Nature, 450, 119-123.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information enzyme disruption mutant, and expression of a fusion protein consisting of the first 506 amino acids of the enzyme fused to a beta-galactosidase/neomycin cassette. The fusion protein lacks the catalytic domain. Presence of the active enzyme is essential for spermatogenesis. Mutant mice exhibit post-meiotic chromatin condensation defects. The enzyme binds directly to and controls the expression of transition nuclear protein 1 and protamine genes Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PCM1
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Source Tissue

Source Tissue Comment Organism Textmining
spermatid protein level is the highest in round spermatids, compared with spermatocyte and elogating spermatids Mus musculus
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spermatocyte protein level is the highest in round spermatids, compared with spermatocyte and elongating spermatids. Protein is not detectable in spermatogonia or gamma-H2AX-positive early pachytene spermatocytes Mus musculus
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testis high expression at both mRNA and protein level, significant increase during spermatogenesis. Expression during and after meiosis, preceding the expression of transition proteins and protamines Mus musculus
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Synonyms

Synonyms Comment Organism
JHDM2A
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Mus musculus
JmjC-domain-containing histone demethylase 2A
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Mus musculus
JMJD1A
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Mus musculus